Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection
نویسندگان
چکیده
منابع مشابه
Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection.
BACKGROUND In phase 2 studies, treatment with the all-oral combination of the nucleotide polymerase inhibitor sofosbuvir and the NS5A inhibitor ledipasvir resulted in high rates of sustained virologic response among previously untreated patients with hepatitis C virus (HCV) genotype 1 infection. METHODS We conducted a phase 3, open-label study involving previously untreated patients with chro...
متن کاملLedipasvir and sofosbuvir for previously treated HCV genotype 1 infection.
BACKGROUND Effective treatment for hepatitis C virus (HCV) genotype 1 infection in patients who have not had a sustained virologic response to prior interferon-based therapy represents an unmet medical need. METHODS We conducted a phase 3, randomized, open-label study involving patients infected with HCV genotype 1 who had not had a sustained virologic response after treatment with peginterfe...
متن کاملLedipasvir-sofosbuvir for hepatitis C genotype 4 infection.
In The Lancet Infectious Diseases, Anita Kohli and colleagues report the results of a single-centre, open-label cohort, phase 2a trial of a ledipasvir plus sofosbuvir fi xed-dose combination (FDC) for adult patients with genotype 4 hepatitis C virus (HCV). The primary endpoint was the proportion of patients achieving a sustained viral response at 12 weeks after the termination of study drugs (S...
متن کاملRelapse of HCV Genotype 1b Infection After Sofosbuvir/Ledipasvir Treatment Presenting as De Novo Cryoglobulinemic Vasculitis
Relapse of hepatitis C virus (HCV) genotype 1 infection after combination therapy with sofosbuvir and ledipasvir is unusual. We report a treatment-naïve, non-cirrhotic patient in whom the relapse of genotype 1b HCV infection was accompanied by de novo cryoglobulinemic vasculitis and glomerulonephritis, requiring hemodialysis for acute renal failure. Sequence analysis revealed several resistance...
متن کاملVirologic response following combined ledipasvir and sofosbuvir administration in patients with HCV genotype 1 and HIV co-infection.
IMPORTANCE There is an unmet need for interferon- and ribavirin-free treatment for chronic hepatitis C virus (HCV) infection in patients co-infected with human immunodeficiency virus (HIV). OBJECTIVE To evaluate the rates of sustained virologic response (SVR) and adverse events in previously untreated patients with HCV genotype 1 and HIV co-infection following a 12-week treatment of the fixed...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2014
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmoa1402454